Safety Evaluation of the Excessive Intake of Ceramide-Containing Acetic Acid Bacteria - A Randomized, Double-Blind, Placebo-Controlled Study Over a 4-week Period

Ceramide plays an important role in maintaining the skin barrier function. Aging and atopic dermatitis are known to reduce levels of ceramide. Application exogenous ceramide can restore In recent years, effect oral intake has been demonstrated improve function, it marketed as a food supplement. Therefore, is provide information on safety unintentional overdose This randomized, double-blind, placebo-controlled study was conducted 30 healthy adults, aged between 20 60 years age (both female male). The subjects consumed either dietary supplement, comprising 1197 mg acetic acid bacteria containing 9.06 ceramide, or placebo for four consecutive weeks. Safety evaluated based physical measurements, blood test, urinalysis, adverse events, side effects. results showed several significant differences measures tests two groups. However, these were considered be unrelated ceramide-containing placebo. Thus, no effects clinically concerning changes physical, blood, urine parameters observed due excessive present study.